The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms
| Autor: | Wing Li, Meng C. Lin, Thao N. Yeh, Tiana Leung, Mariel Lerma, Tiffany Yuen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Moderate to severe
Adult Male medicine.medical_specialty Corneal staining Adolescent Dry Eye Syndromes Signs and symptoms Ophthalmology & Optometry Medical and Health Sciences 03 medical and health sciences dry eye Young Adult 0302 clinical medicine Clinical Research Ophthalmology Surveys and Questionnaires Prevalence Medicine Humans Eye Disease and Disorders of Vision Aged lid wiper epitheliopathy ocular surface Blinking business.industry Prevention Epithelial Cells Middle Aged Biological Sciences eye diseases Contact lens Diverse population soft contact lens Cross-Sectional Studies Tears 030221 ophthalmology & optometry Eyelid Diseases ethnicity Female business Ocular surface 030217 neurology & neurosurgery |
| Zdroj: | Investigative ophthalmology & visual science, vol 59, iss 5 |
| Popis: | Purpose:There has been interest in determining whether lid wiper epitheliopathy (LWE) plays a key role in causing ocular discomfort. Conflicting reports have made it difficult to discern whether LWE is more prevalent in certain populations, what characteristics are associated with its severity, and what its role is in symptomology. This cross-sectional study on a large and diverse population attempts to answer these questions. Methods:Subjects were asked to complete questionnaires related to dry eye and to ocular discomfort. A comprehensive set of ocular surface parameters were assessed, including LWE length and width, tear-film lipid layer thickness, fluorescein tear breakup time (FTBUT), lid-parallel conjunctival folds (LIPCOF), and corneal staining. Results:A total of 287 subjects participated in the study. LWE was observed in 45% of the study cohort and was twice as prevalent in Asians than non-Asians (P < 0.005). LWE was more likely to present in contact lens wearers than non-contact lens wearers (P = 0.03). Decreased FTBUT was associated with increased LWE length and width (P < 0.005 and P = 0.01, respectively), although only a small effect size was noted. Presence of LIPCOF was linked with a 0.25-grade increase in LWE width (P = 0.01). Only LWE width was associated with greater symptoms in contact lens wearers. Conclusions:LWE was associated with decreased tear-film stability, contact lens wear, lid anatomy, and LIPCOF. LWE was not associated with symptoms in non-contact lens wearers. LWE width was associated with greater symptoms in contact lens wearers but was only clinically significant with moderate to severe LWE width. |
| Databáze: | OpenAIRE |
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