Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus
| Autor: | Anna Glaser, George Koike, Luo-Sheng Li, Holger Luthman, Joakim Galli, Michael J. MacDonald, Howard J. Jacob, Ashok Balasubramanyam, Claude Szpirer, Pascale Van Vooren, Masahide Shiozawa, Laura J. Brown |
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| Rok vydání: | 1996 |
| Předmět: |
endocrine system
endocrine system diseases Genetic Linkage medicine.medical_treatment Molecular Sequence Data Restriction Mapping Glycerolphosphate Dehydrogenase Mitochondrion Biology Gene mapping Genetics medicine Animals Humans Cloning Molecular Gene In Situ Hybridization Fluorescence Regulator gene Chromosome localization Insulin nutritional and metabolic diseases Chromosome Mapping Mitochondria Rats Disease Models Animal Chromosome 3 Diabetes Mellitus Type 2 Genetic marker hormones hormone substitutes and hormone antagonists |
| Zdroj: | Genomics. 38(1) |
| ISSN: | 0888-7543 |
| Popis: | The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mtGPD) plays an important role in the regulation of insulin secretion and has been postulated as a candidate responsible for the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) in humans as well as in rodent models of NIDDM. Recent molecular genetic studies of the Goto-Kakizaki (GK) rat model of NIDDM have identified loci linked to NIDDM. To elucidate whether rat mtGPD might play a role in the pathogenesis of NIDDM, the rat mtGPD gene (Gpd2) was cloned, and a genetic marker for Gpd2 was developed. The gene mapped to the region of rat chromosome 3 that contains a region linked to NIDDM in the GK rat. Fluorescence in situ hybridization was also carried out to verify the map position. |
| Databáze: | OpenAIRE |
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