Ventral pallidum self-stimulation: a moveable electrode mapping study
| Autor: | George Panagis, Yannis Anagnostakis, Eleftherios Miliaressis, Christina Spyraki |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Tegmentum Mesencephali Stimulation Globus Pallidus Amygdala Rats Sprague-Dawley Ventral pallidum Behavioral Neuroscience Self Stimulation Nuclear magnetic resonance Dorsal raphe nucleus Neural Pathways Basal ganglia medicine Animals Electrodes Mapping study Appetitive Behavior Brain Mapping Motivation Chemistry Anatomy Rats medicine.anatomical_structure Globus pallidus Sensory Thresholds Electrode Raphe Nuclei |
| Zdroj: | Behavioural Brain Research. 68:165-172 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/0166-4328(94)00169-g |
| Popis: | The distribution of electrical self-stimulation (ESS) foci within the ventral pallidum (VP) was mapped using moveable electrodes in rats. The function relating ESS bar-pressing rate to the frequency of cathodal rectangular pulses (0.4 mA and 0.1 ms) was obtained for several positions of a moveable electrode in the VP and in the various adjacent to VP nuclei. The rate-frequency functions were fitted to a sigmoid model to obtain the asymptotic rate and threshold frequency. ESS was found in almost all (98%) VP sites tested and to a lesser degree (66%) in the surrounding areas (namely globus pallidus and caudate). Depending on the VP site, maximum rates varied from 14 to 85 bar presses/min, whereas threshold frequencies varied from 10.2 to 36.4 pulses/train; no correlation between these two aspects of ESS was found. Extra-pallidal areas contained less low-frequency threshold sites compared to VP. The lowest threshold found in the VP was slightly higher than that usually obtained for the most rewarding brain areas (VTA, dorsal raphé, LH, amygdala), which suggests that the VP represents an important structure for reward. Furthermore the threshold frequencies were found to decline along the rostrocaudal axis of the VP which supports the view that the VP is heterogeneous in regard to reward related functions. |
| Databáze: | OpenAIRE |
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