Distribution of granulopoietic activity in the human skeleton, studied by colony growth in agar diffusion chambers
| Autor: | M. Y. Gordon, I. D. C. Douglas, H. M. Clink, B. M. J. Pickering |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pathology
medicine.medical_specialty Sternum food.ingredient Bone Marrow Cells Cell Count Biology In Vitro Techniques Iliac crest Ilium food Precursor cell medicine Leukocytes Agar Distribution (pharmacology) Humans Tibia Hematology Anatomy Peripheral blood Hematopoiesis Human skeleton medicine.anatomical_structure Bone marrow Granulocytes |
| Zdroj: | British journal of haematology. 32(4) |
| ISSN: | 0007-1048 |
| Popis: | The colony forming ability of bone marrow cells from 110 haemato-logically normal patients was investigated by their growth in semi-solid agar in intraperitoneal diffusion chambers. Marrow aspirated from the sternum showed a consistently higher colony yield than that from the iliac crest. Study of site variation in the individual was possible in donors for bone marrow transplantation. In each of four cases, sternal marrow produced more colonies than any other site. Examination of smears made from the aspirated samples suggested that the difference in yield was not due to varying dilution by peripheral blood on aspiration from different sites. It is concluded, therefore, that the incidence of colony precursor cells is not uniform throughout the active marrow. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text