Tadalafil attenuates ischemic damage as well as reperfusion injury in the rat ovary
| Autor: | Nuri Yildirim, Gurkan Yigitturk, Cagdas Sahin, Ali Akdemir, Ismet Hortu, Serdar Özşener, Oytun Erbaş |
|---|---|
| Přispěvatelé: | Ege Üniversitesi, MÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
ischemia-reperfusion injury Vasodilatation Ischemia lcsh:Medicine Ovary Vasodilation lcsh:Gynecology and obstetrics Tadalafil 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine 030212 general & internal medicine Cyclic guanosine monophosphate lcsh:RG1-991 Original Investigation Ischemia-Reperfusion Injury 030219 obstetrics & reproductive medicine business.industry anti-oxidant lcsh:R Phosphodiesterase type-5 Ovarian torsion Obstetrics and Gynecology Anti-Oxidant medicine.disease Malondialdehyde vasodilatation Endocrinology medicine.anatomical_structure chemistry Phosphodiesterase Type-5 business Reperfusion injury tadalafil medicine.drug |
| Zdroj: | Journal of the Turkish-German Gynecological Association, Vol 21, Iss 1, Pp 35-40 (2020) Journal of the Turkish German Gynecological Association |
| Popis: | sahin, cagdas/0000-0001-7346-3987 WOS: 000519555600008 PubMed ID: 31088044 Objective: Tadalafil is a selective phosphodiesterase type-5 inhibitor with a long half-life. It has a dual function in ischaemic and re-perfused tissues, i.e. vasodilatation and anti-oxidant effects. These features of tadalafil distinguish it from other anti-oxidants. We investigated the dual effect of tadalafil on ischaemia and reperfusion injury in the rat ovary. Material and Methods: We established five study groups. Group 1 (n=6): sham-operated; group 2 (n=6): torsion; group 3 (n=6): torsion and Tadalafil; group 4 (n=6): torsion/de-torsion; and group 5 (n=6): torsion/de-torsion and tadalafil. Ovarian samples were harvested from animals and evaluated in terms of histopathologic changes, tissue malondialdehyde (MDA) concentrations, lactate production, and plasma cyclic guanosine monophosphate (cGMP). Results: Follicular degeneration, oedema, haemorrhage, and inflammatory cells were significantly decreased in group 5 in comparison with group 4. Group 2 and group 3 were compared in terms of vascular congestion and haemorrhage; these parameters were significantly decreased in group 3. In addition, significantly decreased MDA and lactate concentrations were observed in group 5 in comparison with group 4. Increased cGMP concentrations were detected in group 3 and group 5. Conclusion: We conclude that tadalafil might be useful in protecting the ovary against ischaemia and reperfusion injury. In the evet of ovarian torsion, it will provide a greater therapeutic effect than only performing de-torsion of the ovary or using other anti-oxidant agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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