Bismuth Phosphinates in Bi-Nanocellulose Composites and their Efficacy towards Multi-Drug Resistant Bacteria
| Autor: | Rajini Brammananth, Paul K. Crellin, Uthpala M. Garusinghe, Warren Batchelor, Melissa V. Werrett, Megan E. Herdman, Ross L. Coppel, Philip C. Andrews |
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| Rok vydání: | 2018 |
| Předmět: |
Silver
Cell Survival Gram-positive bacteria chemistry.chemical_element 02 engineering and technology Microbial Sensitivity Tests 010402 general chemistry medicine.disease_cause 01 natural sciences Catalysis Nanocellulose Bismuth Nanocomposites chemistry.chemical_compound Structure-Activity Relationship Drug Stability Drug Resistance Multiple Bacterial Chlorocebus aethiops medicine Animals Humans Agar diffusion test Cellulose Particle Size biology Organic Chemistry General Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Phosphinic Acids 0104 chemical sciences Anti-Bacterial Agents chemistry Solubility Staphylococcus aureus COS Cells 0210 nano-technology Antibacterial activity Bacteria Nuclear chemistry |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 24(49) |
| ISSN: | 1521-3765 |
| Popis: | A series of poorly soluble phenyl bis-phosphinato bismuth(III) complexes [BiPh(OP(=O)R1 R2 )2 ] (R1 =R2 =Ph; R1 =R2 =p-OMePh; R1 =R2 =m-NO2 Ph; R1 =Ph, R2 =H; R1 =R2 =Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano-) cellulose generating a bismuth-cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi-cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43 wt % into nanocellulose produces a 10 mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph2 )2 ] loaded at 0.34 wt % produces an 18 mm zone of inhibition. These phenyl bis-phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease. |
| Databáze: | OpenAIRE |
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