Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer
| Autor: | Yu-Wen Tien, Hung-Chih Chen, Chia-Hsin Hsu, Chaw Yee Beh, Li-Lun Chen, Shao-Chan Huang, Keng-Jung Lee, Di-Yen Chueh, Timothy J. Kamp, Oi Kuan Choong, Xu-En Yu, Ray Putra Prajnamitra, Chiung Wen Kuo, San-Shan Huang, Patrick C.H. Hsieh, Peilin Chen, Tsai-Chen Chiang, Cheng-Bang Jian, James J. Lai, Hsien-Ming Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Heart Diseases
Heart disease Cell Monocytes Metastasis 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans Health and Medicine Research Articles 030304 developmental biology 0303 health sciences Multidisciplinary business.industry Monocyte SciAdv r-articles Life Sciences Cancer medicine.disease Pancreatic Neoplasms medicine.anatomical_structure Reperfusion Injury 030220 oncology & carcinogenesis Toxicity Circulatory system Cancer research business Research Article Carcinoma Pancreatic Ductal |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abf2400 |
| Popis: | Aptamer-based nanovectors that actively bind to circulating monocytes enhance drug delivery to the heart and to cancer. The delivery of therapeutics through the circulatory system is one of the least arduous and less invasive interventions; however, this approach is hampered by low vascular density or permeability. In this study, by exploiting the ability of monocytes to actively penetrate into diseased sites, we designed aptamer-based lipid nanovectors that actively bind onto the surface of monocytes and are released upon reaching the diseased sites. Our method was thoroughly assessed through treating two of the top causes of death in the world, cardiac ischemia-reperfusion injury and pancreatic ductal adenocarcinoma with or without liver metastasis, and showed a significant increase in survival and healing with no toxicity to the liver and kidneys in either case, indicating the success and ubiquity of our platform. We believe that this system provides a new therapeutic method, which can potentially be adapted to treat a myriad of diseases that involve monocyte recruitment in their pathophysiology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|