Synthesis of 3,5-Disubstituted Piperazinones via Palladium(II)-Catalyzed Amination

Autor:	Benoit Ferber, Sophie Vogel, Guillaume Prestat, David Madec, Giovanni Poli
Rok vydání:	2006
Předmět:	inorganic chemicals Allylic rearrangement Chemistry Organic Chemistry food and beverages chemistry.chemical_element General Medicine Medicinal chemistry Catalysis Irreversible process Intramolecular force Organic chemistry Stereoselectivity Amination Palladium
Zdroj:	Synlett. 2006:2133-2135
ISSN:	1437-2096 0936-5214
Popis:	The synthesis of 3,5-disubstituted piperazinones has been achieved in quantitative yields via an intramolecular palladium(II)-catalyzed allylic amination in the presence of LiCl and without a reoxidizing system. These conditions, that allow higher diastereoselectivities than those reported earlier using Pd(0), are associated to a different and irreversible process. Conveniently, the stereoselectivity is reversed if the reaction is performed in the absence of LiCl.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63a4474d4aeb3ab55d885f492d16a6d https://doi.org/10.1055/s-2006-948208 Zobrazit plný text záznamu