Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown
| Autor: | My Dung Vuu, Masamitsu Yamaguchi, Man Anh Huynh, Thi Phuong Thao Dang, Linh Thuoc Tran, Thi Thanh Sang Nguyen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Aging Curcumin Article Subject Population PINK1 Pharmacology Biology medicine.disease_cause Biochemistry Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals lcsh:QH573-671 education education.field_of_study Gene knockdown Behavior Animal lcsh:Cytology Neurodegeneration Parkinson Disease Cell Biology General Medicine medicine.disease LRRK2 Oxidative Stress Drosophila melanogaster Neuroprotective Agents 030104 developmental biology chemistry Drosophila Reactive Oxygen Species Ubiquitin Thiolesterase 030217 neurology & neurosurgery Oxidative stress Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2018 (2018) |
| ISSN: | 1942-0994 1942-0900 |
| DOI: | 10.1155/2018/2038267 |
| Popis: | The relationship between oxidative stress and neurodegenerative diseases has been extensively examined, and antioxidants are considered to be a promising approach for decelerating disease progression. Parkinson’s disease (PD) is a common neurodegenerative disorder and affects 1% of the population over 60 years of age. A complex combination of genetic and environmental factors contributes to the pathogenesis of PD. However, since the onset mechanisms of PD have not yet been elucidated in detail, difficulties are associated with developing effective treatments. Curcumin has been reported to have neuroprotective properties in PD models induced by neurotoxins or genetic factors such as α-synuclein, PINK1, DJ-1, and LRRK2. In the present study, we investigated the effects of curcumin in a novel Drosophila model of PD with knockdown of dUCH, a homolog of human UCH-L1. We found that dopaminergic neuron-specific knockdown of dUCH caused impaired movement and the loss of dopaminergic neurons. Furthermore, the knockdown of dUCH induced oxidative stress while curcumin decreased the ROS level induced by this knockdown. In addition, dUCH knockdown flies treated with curcumin had improved locomotive abilities and less severe neurodegeneration. Taken together, with studies on other PD models, these results strongly suggest that treatments with curcumin are an appropriate therapy for PD related to oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text