Platelet Monoamine Oxidase and Serum Dopamine-β-Hydroxylase Activity in Chronic Alcoholics
| Autor: | Jesse O. Cavenar, Sullivan Jl, Charles N. Stanfield, Saul M. Schanberg |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Dopamine beta-Hydroxylase Arts and Humanities (miscellaneous) Internal medicine Dopamine β hydroxylase Humans Medicine Decompensation Platelet Longitudinal Studies Platelet monoamine oxidase Monoamine Oxidase business.industry Chronic alcoholic Mao activity Middle Aged Pathophysiology Acute alcoholism Alcoholism Psychiatry and Mental health Endocrinology Anesthesia Acute Disease business |
| Zdroj: | Archives of General Psychiatry. 35:1209 |
| ISSN: | 0003-990X |
| Popis: | Previous independent reports suggest that low platelet monoamine oxidase (MAO) activity and high serum dopamine-beta-hydroxylase (DBH) activity may be associated with alcoholism or vulnerability toward alcoholism. However, there are also contradictory reports in the literature with regard to each of these two enzymes. We measured both platelet MAO and serum DBH activity in alcoholics followed up at periodic intervals for 12 months after hospitalization for acute alcoholism. Platelet MAO activity in the alcoholics was significantly lower compared to that of nonpsychiatric controls throughout the 12-month period, whereas serum DBH activity in the alcoholics was essentially the same as control values. Thus, low platelet MAO activity, previously reported in a spectrum of clinical psychiatric disorders, appears to be a relatively stable phenomenon in chronic alcoholics irrespective of acute intoxication or pathophysiological factors associated with acute decompensation in individuals vulnerable to alcoholism. |
| Databáze: | OpenAIRE |
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