Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat

Autor: Sihame Ouakki, Oussama Zghari, Aboubaker El Hessni, Ali Ouichou, Abdelhalem Mesfioui, Mouloud Lamtai, Sofia Azirar
Rok vydání: 2020
Předmět:
Male
Elevated plus maze
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Intraperitoneal injection
Morris water navigation task
010501 environmental sciences
medicine.disease_cause
Hippocampus
01 natural sciences
Biochemistry
Antioxidants
Open field
Inorganic Chemistry
Lipid peroxidation
Melatonin
03 medical and health sciences
chemistry.chemical_compound
hemic and lymphatic diseases
Internal medicine
medicine
Animals
Hippocampus (mythology)
Cognitive Dysfunction
Rats
Wistar
Maze Learning
0105 earth and related environmental sciences
0303 health sciences
business.industry
030302 biochemistry & molecular biology
Biochemistry (medical)
General Medicine
Rats
Oxidative Stress
Endocrinology
chemistry
Female
Lipid Peroxidation
business
Oxidative stress
Cadmium
medicine.drug
Zdroj: Biological Trace Element Research. 199:1445-1455
ISSN: 1559-0720
0163-4984
DOI: 10.1007/s12011-020-02247-z
Popis: The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Mel (4 mg/kg) for 8 weeks. Behavioral disorders were evaluated by different tests mainly the open field and elevated plus maze tests for anxiety-like behavior, forced swimming test (FST) for depression-like behavior, and the Y-maze and Morris water maze (MWM) tests for cognitive disorders. Thereafter, oxidative stress indices and histology of the hippocampus were evaluated. The results confirm that Cd administration has anxiogenic-like effects in both anxiety tests and depressive-like effects in the FST and leads to memory and learning disabilities in the Y-maze and MWM. We also report that Mel counteracts these neurobehavioral disorders. Biochemical assays showed that rats intoxicated with Cd significantly increased levels of nitric oxide (NO) and lipid peroxidation (LPO), while the activities of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased in the hippocampus. In contrast, Mel administration attenuates the Cd-induced changes. The histopathological studies in the hippocampus of rats also supported that Mel markedly reduced the Cd-induced neuronal loss in CA3 sub-region. Overall, our results suggest that Mel could be used to protect against Cd-induced neurobehavioral changes via its antioxidant properties in the hippocampus. The effects of Cd and Mel are sex-dependent, knowing that Cd is more harmful in males, while Mel is more protective in females.
Databáze: OpenAIRE
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