Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypes
| Autor: | Patricia Claeys, Herman Depypere, Marleen Temmerman, Marleen Praet, Claude Cuvelier, Y. Sturtewagen, E. Beerens, L Van Renterghem, Steven Weyers |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Hpv genotypes medicine.medical_specialty Histology Adolescent Genotype Cytodiagnosis Uterine Cervical Neoplasms Cervix Uteri Comorbidity Pathology and Forensic Medicine Age Distribution Belgium Prevalence Humans Mass Screening Medicine Papillomaviridae Human papillomavirus DNA detection Cervix Mass screening Aged Aged 80 and over Gynecology Cervical screening biology business.industry Papillomavirus Infections virus diseases General Medicine Middle Aged biology.organism_classification Abnormal cytology medicine.anatomical_structure DNA Viral Female business |
| Zdroj: | Cytopathology. 16:199-205 |
| ISSN: | 1365-2303 0956-5507 |
| DOI: | 10.1111/j.1365-2303.2005.00266.x |
| Popis: | Objectives: In this study, we focus on the prevalence and occurrence of different anogenital human papillomavirus (HPV) genotypes in a first abnormal cervical screening test, and correlate HPV genotyping with the cytological diagnosis on thin-layer liquid-based preparations in routine gynaecological screening. Methods: Out of 780 abnormal smears, 513 tested positive for HPV. All 25 different HPV types were identified by Line Probe Assay. Results: The prevalence of high-risk HPV types increased from 72% in atypical squamous cell of undetermined significance to 94.5% in high-grade intra-epithelial lesion (HSIL). Co-infection with multiple HPV types was predominantly found in HSIL (35.8%). In the HSIL group the most common HPV types were 16, 52, 51 and 31; type 18 was rarely present. Conclusion: The role of types 31, 51 and 52 should be considered in future studies on vaccine development. |
| Databáze: | OpenAIRE |
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