Inflammatory profile and white matter hyperintensity burden in acute ischemic stroke patients
| Autor: | Rascle, L., Nighoghossian, N., Cho, T. H., Bochaton, T., Paccalet, A., Crola da Silva, C., Buisson, Marielle, Amaz, C., Fontaine, J., Ong, E., Derex, L., Berthezene, Y., Eker, O. F., Mewton, N., Ovize, M., Mechtouff, L. |
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| Přispěvatelé: | Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Investigation Clinique [Bron] (CIC1407), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupement Hospitalier Est [Bron], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CarMeN, laboratoire |
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
[SDV]Life Sciences [q-bio] Immunology Cerebral small vessel diseases Magnetic Resonance Imaging White Matter Blood biomarkers Brain Ischemia Reperfusion injury [SDV] Life Sciences [q-bio] Stroke Neurology Immunology and Allergy Humans Neurology (clinical) Biomarkers Thrombectomy Ischemic Stroke |
| Zdroj: | Journal of Neuroimmunology Journal of Neuroimmunology, 2022, 371, pp.577934. ⟨10.1016/j.jneuroim.2022.577934⟩ |
| ISSN: | 1872-8421 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2022.577934⟩ |
| Popis: | International audience; Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses. WMH burden is not associated with a specific inflammatory profile in AIS. |
| Databáze: | OpenAIRE |
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