Influence of Age and Nature of Primary Infection on Varicella‐Zoster Virus–Specific Cell‐Mediated Immune Responses
| Autor: | Jeffrey L. Silber, Myron J. Levin, Gary O. Zerbe, Kenny H. Chan, Anthony R. Hayward, Rob Roy MacGregor, Anne A. Gershon, Ivan S. F. Chan, Adriana Weinberg, Rupert Vessey, Ann A. Lazar |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Herpesvirus 3 Human Adolescent Varicella vaccine viruses HIV Infections medicine.disease_cause Article Virus Herpesviridae Chickenpox Vaccine Chickenpox Immunity medicine Humans Immunology and Allergy Longitudinal Studies Child Aged Aged 80 and over Immunity Cellular integumentary system business.industry Age Factors Varicella zoster virus Infant virus diseases Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Virology Vaccination Logistic Models Infectious Diseases Child Preschool Immunology Zoster vaccine business medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 201:1024-1030 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Varicella-zoster virus (VZV)–specific cell-mediated immunity responses are essential for recovery from primary (varicella) or reactivation (herpes zoster) infection with VZV [1-4]. Patients who lack adequate VZV-specific cell-mediated immunity often have severe and prolonged infections with VZV, some of which are fatal [3-5]. Thus, VZV-specific cell-mediated immunity is a marker for protection against primary VZV infection, and the presence and magnitude of this response correlates with recovery from varicella and with the incidence and severity of reactivation as manifested by herpes zoster. VZV-specific cell-mediated immunity is also a component of primary responses to varicella vaccine administered to susceptible children and adults and has been used to evaluate candidate vaccines to prevent herpes zoster in immunocompromised and elderly individuals [6-9]. In this report, we present a regression model of VZV-specific memory CD4 responses as a function of age, from early childhood to advanced adulthood among healthy individuals with prior VZV wild-type infectionas a reference against which responses of other select groups of individuals are compared. Comparisons are made to elderly recipients of a zoster vaccine and to human immunodeficiency virus (HIV)–infected children and adults. We demonstrate that VZV-specific cell-mediated immunity is determined by the nature of primary immunization (natural infection vs VZV vaccination) and the age and immune status of the subject tested. |
| Databáze: | OpenAIRE |
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