Dextromoramide pharmacokinetics following sublingual administration
| Autor: | D. Thorne, N. C. Saccoia, T. E. Jones, Raymond G. Morris |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Sublingual use
Male Time Factors Administration Sublingual Absorption (skin) Sublingual administration Absorption 03 medical and health sciences 0302 clinical medicine Pharmacokinetics 030502 gerontology Medicine Humans Dextromoramide Aged business.industry General Medicine Middle Aged Analgesics Opioid Anesthesiology and Pain Medicine Opioid 030220 oncology & carcinogenesis Anesthesia Rapid onset Time to peak Female Analgesia 0305 other medical science business medicine.drug |
| Zdroj: | Palliative medicine. 10(4) |
| ISSN: | 0269-2163 |
| Popis: | The extent of absorption and other pharmacokinetic parameters of dextromoramide following sublingual administration were assessed in five patients receiving chronic opioid analgesia. The use of the standard 5 mg tablet formulation was associated with negligible absorption in two patients, a prolonged time to peak concentration in the other three and substantial variability in clearance. The study concluded that the standard tablet formulation cannot be recommended for sublingual use where reliable, rapid onset analgesia is required. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|