Factors associated with granulocyte colony-stimulating factor-induced peripheral blood stem cell yield in healthy donors
| Autor: | Shoji Kagami, Yoichi Takaue, Tsutomu Watanabe, Yoshifumi Kawano, Toshihiro Onishi, Takanori Abe, Ryuji Nakagawa, Yasuhiro Okamoto, Hiroko Suzuya, Hiroyoshi Watanabe |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Hematopoietic stem cell transplantation Peripheral blood mononuclear cell Blood cell Andrology White blood cell Granulocyte Colony-Stimulating Factor medicine Humans Leukapheresis Child Hematopoietic Stem Cell Mobilization Mobilization business.industry Age Factors Hematopoietic Stem Cell Transplantation Hematology General Medicine Middle Aged Hematopoietic Stem Cells Recombinant Proteins Tissue Donors Granulocyte colony-stimulating factor medicine.anatomical_structure Child Preschool Immunology Female business |
| Zdroj: | Vox sanguinis. 89(4) |
| ISSN: | 0042-9007 |
| Popis: | Background and Objectives Poor collection results are a clinical problem in granulocyte-colony stimulating factor (G-CSF)-induced peripheral blood stem cell (PBSC) collection in healthy donors. It would be beneficial to be able to predict the PBSC yield from allogeneic donors before mobilization or harvesting. Materials and Methods We examined the relationship between certain donor characteristics and the effectiveness of G-CSF-induced PBSC collection in 59 healthy family donors aged 3–63 years old (median 16 years). G-CSF was administered subcutaneously at 10 µg/kg for mobilization, daily for 5 days, and PBSC harvest using a continuous blood cell separator was started on day 5 of G-CSF treatment. Total cell yields were calculated as the number per unit of processed blood (l) per unit weight of the donor (kg). Results In a univariate analysis, the donor's age, body mass index (BMI), white blood cell (WBC) count before mobilization, and platelet count before and during mobilization were significantly correlated with the yield of mononuclear cells (MNC), CD34+ cells and granulocyte–macrophage colony-forming units (GM-CFU). Younger age (P < 0·001), a low BMI (P = 0·002), a high WBC count before mobilization (P = 0·004), a high platelet count before (P = 0·012) and during (P |
| Databáze: | OpenAIRE |
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