The association between genetic variants in the genes for cytochrome P450 B1 and ATP-binding cassette transporter genes and breast cancer risk
| Autor: | Hamideh Ghazizade, Gordon A. Ferns, Davood Radmanesh, Amir Avan, Soodabeh Shahidsales, Mehrane Mehramiz, Azam Rastgar-Moghadam, Seyed Mahdi Hassanian, Majid Khazaei |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Genotype medicine.drug_class CYP1B1 Population Breast Neoplasms Locus (genetics) Iran Polymorphism Single Nucleotide Risk Assessment 03 medical and health sciences 0302 clinical medicine Breast cancer Gene Frequency Internal medicine Genetics Humans Medicine Genetic Predisposition to Disease education Molecular Biology Gene Alleles education.field_of_study business.industry General Medicine Middle Aged medicine.disease Tumor Burden Genotype frequency Cross-Sectional Studies 030104 developmental biology Estrogen Case-Control Studies 030220 oncology & carcinogenesis Cytochrome P-450 CYP1B1 Female business |
| Zdroj: | Molecular Biology Reports. 47:6009-6014 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-020-05674-2 |
| Popis: | Breast cancer is among the most common malignancies in women. Recent studies have shown that polymorphisms in genes involved in the metabolism and transport of anticancer drugs are associated with outcomes of several malignancies, e.g., breast cancer. In this study we evaluate whether CYP1B1/rs1056836 and ABCB1/rs2032582 gene variants are associated with breast cancer. Eighty eight cases and 200 controls, were genotyped for polymorphisms of the CYP1B1 and ABCB1 genes using Taqman®-based methods. Logistic regression was also used to test the associations between breast cancer risk and the various genotypes involved. The GG genotype of rs2032582 locus had a frequency of 43.5% with 0.38 MAF; while the GT and TT genotypes in the control group were 40% and 16.5%, respectively. The GG, GT and TT genotype frequencies in the patients with breast cancer were 45.5%, 12.5% and 26.1%, respectively. An association was observed between the TT genotype of ABCB1/rs2032582 locus and a larger breast cancer tumor size (P |
| Databáze: | OpenAIRE |
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