Magnetic Graphene Oxide Nanocarrier for Targeted Delivery of Cisplatin: A Perspective for Glioblastoma Treatment
| Autor: | Manuela Curcio, Florida Voli, Fiore Pasquale Nicoletta, Annafranca Farfalla, Francesca Iemma, Giuseppe Cirillo, Ahmed A. El-Gendy, Silke Hampel, Orazio Vittorio, Emanuele Valli, Gerardo F. Goya, Sami A Makharza |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Oxide lcsh:Medicine lcsh:RS1-441 Pharmaceutical Science Nanoparticle cisplatin 02 engineering and technology 010402 general chemistry 01 natural sciences Article law.invention lcsh:Pharmacy and materia medica Magnetization chemistry.chemical_compound law Drug Discovery neoplasms Magnetite Graphene lcsh:R technology industry and agriculture glioblastoma Coercivity equipment and supplies 021001 nanoscience & nanotechnology nervous system diseases 0104 chemical sciences maghemite magnetic targeting chemistry Chemical engineering Drug delivery Molecular Medicine graphene oxide Nanocarriers 0210 nano-technology human activities |
| Zdroj: | Pharmaceuticals Pharmaceuticals, Vol 12, Iss 2, p 76 (2019) Zaguán. Repositorio Digital de la Universidad de Zaragoza instname Volume 12 Issue 2 |
| ISSN: | 1424-8247 |
| Popis: | Selective vectorization of Cisplatin (CisPt) to Glioblastoma U87 cells was exploited by the fabrication of a hybrid nanocarrier composed of magnetic &gamma Fe2O3 nanoparticles and nanographene oxide (NGO). The magnetic component, obtained by annealing magnetite Fe3O4 and characterized by XRD measurements, was combined with NGO sheets prepared via a modified Hummer&rsquo s method. The morphological and thermogravimetric analysis proved the effective binding of &gamma Fe2O3 nanoparticles onto NGO layers. The magnetization measured under magnetic fields up to 7 Tesla at room temperature revealed superparamagnetic-like behavior with a maximum value of MS = 15 emu/g and coercivity HC &asymp 0 Oe within experimental error. The nanohybrid was found to possess high affinity towards CisPt, and a rather slow fractional release profile of 80% after 250 h. Negligible toxicity was observed for empty nanoparticles, while the retainment of CisPt anticancer activity upon loading into the carrier was observed, together with the possibility to spatially control the drug delivery at a target site. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |