Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients
| Autor: | Javier Fernández-Sánchez, Antonio Palazón-Bru, Maria Ruano-Zaragoza, Maria Luisa Somoza, Victor Soriano-Gomis, Angel Esteban-Rodriguez, Teodorikez Wilfox Jimenez-Rodriguez, Purificación Gonzalez-Delgado, Miguel Blanca |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Allergy Adolescent Immunology Immunoglobulin E medicine.disease_cause Risk Assessment Diagnosis Differential Young Adult 03 medical and health sciences 0302 clinical medicine Allergen Oral allergy syndrome Risk Factors Food allergy medicine Humans Immunology and Allergy 030223 otorhinolaryngology Anaphylaxis Sensitization Aged Plant Proteins Asthma biology business.industry Incidence General Medicine Antigens Plant Middle Aged medicine.disease Cross-Sectional Studies medicine.anatomical_structure 030228 respiratory system biology.protein Female Carrier Proteins business |
| Zdroj: | International Archives of Allergy and Immunology. 182:425-432 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000511977 |
| Popis: | Background: Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. Objective: The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens. Methods: This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay. Results: Our sample consisted of 421 people with a mean age of 33.25 years (range 16–68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies. Conclusion: Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated. |
| Databáze: | OpenAIRE |
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