Hypertrophic Cardiomyopathy With Type I CD36 Deficiency
| Autor: | Yoshifusa Aizawa, Yusuke Ogawa, Yuji Ohkura, Ken Toba, Takafumi Nagatomo, Kenichi Watanabe, Haruo Hanawa, Ichiro Fuse, Satoru Hirono, Go Hasegawa, Makoto Naito, Yuichi Nakamura, Yoshinori Aoki, Seiichi Miyajima, Yoriko Kusano, Makoto Kodama |
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| Rok vydání: | 1998 |
| Předmět: |
CD36 Antigens
Male medicine.medical_specialty Heart disease Physiology CD36 Pathogenesis Internal medicine parasitic diseases medicine Humans Platelet biology Myocardium Cardiac muscle Hypertrophic cardiomyopathy hemic and immune systems Cardiomyopathy Hypertrophic Middle Aged medicine.disease Endothelial stem cell medicine.anatomical_structure Endocrinology biology.protein lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine circulatory and respiratory physiology Lipoprotein |
| Zdroj: | Japanese Circulation Journal. 62:541-542 |
| ISSN: | 1347-4839 0047-1828 |
| Popis: | CD36 is a multifunctional membrane-type receptor glycoprotein that reacts with oxidized low-density lipoprotein and long-chain fatty acid (LCFA). A patient presented with hereditary hypertrophic cardiomyopathy (HCM) and type I CD36 deficiency (neither platelets nor monocytes expressed CD36) but showed no myocardial LCFA accumulation. CD36 was expressed in the capillary endothelial cells of the cardiac muscle of a control subject, while the patient's myocardial capillary endothelial cells were completely CD36-negative. These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation. (Jpn Circ J 1998; 62: 541 - 542) |
| Databáze: | OpenAIRE |
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