Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
| Autor: | Yamila Raquel Juarez, Sofía Quiroga, Mariana Lorena Tellechea, Miriam Ruth Wald, Adriana Laura Burgueño, Ana María Genaro, Andrés Prochnik |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Offspring medicine.medical_treatment Medicine (miscellaneous) Adipose tissue Diet High-Fat Mice 03 medical and health sciences 0302 clinical medicine Metabolic Diseases Pregnancy Internal medicine medicine Animals Mice Inbred BALB C Fetus business.industry Leptin Insulin medicine.disease Obesity Disease Models Animal 030104 developmental biology Endocrinology Prenatal stress Female Resistin business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Developmental Origins of Health and Disease. 12:721-730 |
| ISSN: | 2040-1752 2040-1744 |
| DOI: | 10.1017/s2040174420000987 |
| Popis: | Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1. When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels. |
| Databáze: | OpenAIRE |
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