Histamine excites pedunculopontine neurones in guinea pig brainstem slices
| Autor: | Mauro Serafin, Michel Muhlethaler, Asaid Khateb |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Tetrodotoxin/pharmacology Mepyramine Guinea Pigs Action Potentials Aminopyridines Tetrodotoxin Histamine H1 receptor In Vitro Techniques Biology Pons/drug effects/ physiology Action Potentials/drug effects Histamine/ pharmacology Aminopyridines/ pharmacology chemistry.chemical_compound Histamine receptor Histamine H2 receptor Pons Internal medicine medicine Animals Cimetidine Pyrilamine/ pharmacology Pyrilamine General Neuroscience Depolarization ddc:616.8 Endocrinology chemistry Excitatory postsynaptic potential Receptors Histamine Histamine Receptors Histamine/drug effects/ physiology medicine.drug |
| Zdroj: | Neuroscience Letters, Vol. 112, No 2-3 (1990) pp. 257-262 |
| ISSN: | 0304-3940 |
| Popis: | Intracellular recordings were obtained from pedunculopontine tegmental nuclei neurones in guinea pig brainstem slices. These neurones were characterized by the presence of a slow regular firing (around 3 spikes/s), a broad action potential (more than 1 ms) and a transient rectification indicating the presence of an A current. Bath-application of histamine at 10(-4) or 10(-5) M induced a reversible increase in spontaneous firing. In presence of tetrodotoxin (1 microM), the effect of histamine was a reversible membrane depolarization. It was a direct effect as it persisted in presence of a low calcium/high magnesium solution. This excitatory action was presumably mediated by histamine H1 receptors as it could be blocked by the H1 receptor antagonist mepyramine but not by the H2 receptor antagonist cimetidine. A role in arousal is discussed. |
| Databáze: | OpenAIRE |
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