Immunohistochemical expression of keratins 6, 7, 8, 14, 16, 18, 19, and MNF-116 pancytokeratin in primary and metastatic melanoma of the head and neck
| Autor: | Niveen Abdullah, Rima A. Safadi, Maher A. Sughayer, Dima H. Bader |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty macromolecular substances Pathology and Forensic Medicine Immunoenzyme Techniques 03 medical and health sciences Sinonasal undifferentiated carcinoma 0302 clinical medicine Neuroblastoma medicine Biomarkers Tumor Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) neoplasms Anaplastic large-cell lymphoma Melanoma Aged Aged 80 and over integumentary system Olfactory Neuroblastoma business.industry Mucosal melanoma Middle Aged medicine.disease 030104 developmental biology Nasopharyngeal carcinoma Head and Neck Neoplasms 030220 oncology & carcinogenesis Keratins Surgery Female Sarcoma Oral Surgery business |
| Zdroj: | Oral surgery, oral medicine, oral pathology and oral radiology. 121(5) |
| ISSN: | 2212-4411 |
| Popis: | Objective To investigate the immunohistochemical expression (IHCE) of selected keratins in primary cutaneous and mucosal melanoma (pM), and metastatic melanoma (metsM) of the head and neck and to compare their expression to a group of undifferentiated/poorly differentiated tumors of the same anatomic region. Study Design IHCE of K6, K7, K8, K14, K16, K18, and K19 were studied in 29 melanomas and 70 cases of non-melanoma tumors of the same anatomic region (neuroendocrine carcinoma, neuroblastoma, olfactory neuroblastoma, sinonasal undifferentiated carcinoma, undifferentiated nasopharyngeal carcinoma, anaplastic large cell lymphoma, poorly differentiated squamous cell carcinoma (PDSCC), and Ewing sarcoma). MNF-116 pancytokeratin was investigated in melanoma. Results All studied keratins, except K6, were expressed in melanoma. IHCE of MNF-116, K8, and K18 was higher in metsM compared with pM. K14 and K16 expression was highest in PDSCC. Conclusions metsM expresses keratins more than pM, specifically K8, K18, and MNF-116. Keratin positivity in an undifferentiated or poorly differentiated neoplasm does not necessarily exclude the diagnosis of melanoma. |
| Databáze: | OpenAIRE |
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