Memory of occasional events in rats: individual episodic memory profiles, flexibility, and neural substrate
| Autor: | Marina Allerborn, Jana Kenney, Frederic Michon, Nadine Ravel, Marc Thevenet, Samuel Garcia, Serge Laroche, Louise Raguet, Florette Godinot, Alexandra Veyrac, Belkacem Messaoudi, Alexandra Gros |
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| Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Centre de Neurosciences Paris-Sud (CNPS), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), RAVEL, Nadine |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Reconstructive memory hippocampus recollection [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Drinking Behavior Statistics Nonparametric Memory Explicit memory Animals Semantic memory Rats Long-Evans GABA-A Receptor Agonists [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Episodic memory Early Growth Response Protein 1 Brain Mapping Communication prefrontal cortex Water Deprivation Recall [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Muscimol Long-term memory Autobiographical memory business.industry General Neuroscience [SCCO.NEUR]Cognitive science/Neuroscience episodic-like memory [SCCO.NEUR] Cognitive science/Neuroscience rodent Association Learning [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Articles Rats Episodic-like memory Odorants [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] olfactory memory Psychology business Proto-Oncogene Proteins c-fos Cognitive psychology |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2015, 35 (19), pp.7575-86. ⟨10.1523/JNEUROSCI.3941-14.2015⟩ Journal of Neuroscience, 2015, 35 (19), pp.7575-7586. ⟨10.1523/JNEUROSCI.3941-14.2015⟩ Journal of Neuroscience, 2015, 35 (19), pp.7575-7586. ⟨10.1523/jneurosci.3941-14.2015⟩ |
| ISSN: | 0270-6474 1529-2401 |
| Popis: | International audience; In search for the mechanisms underlying complex forms of human memory, such as episodic recollection, a primary challenge is to develop adequate animal models amenable to neurobiological investigation. Here, we proposed a novel framework and paradigm that provides means to quantitatively evaluate the ability of rats to form and recollect a combined knowledge of what happened, where it happened, and when or in which context it happened (referred to as episodic-like memory) after a few specific episodes in situations as close as possible to a paradigm we recently developed to study episodic memory in humans. In this task, rats have to remember two odor-drink associations (what happened) encountered in distinct locations (where it happened) within two different multisensory enriched environments (in which context/occasion it happened), each characterized by a particular combination of odors and places. By analyzing licking behavior on each drinking port, we characterized quantitatively individual recollection profiles and showed that rats are able to incidentally form and recollect an accurate, long-term integrated episodic-like memory that can last ≥ 24 d after limited exposure to the episodes. Placing rats in a contextually challenging recollection situation at recall reveals the ability for flexible use of episodic memory as described in humans. We further report that reversible inactivation of the dorsal hippocampus during recall disrupts the animal's capacity to recollect the complete episodic memory. Cellular imaging of c-Fos and Zif268 brain activation reveals that episodic memory recollection recruits a specific, distributed network of hippocampal-prefrontal cortex structures that correlates with the accuracy of the integrated recollection performance. |
| Databáze: | OpenAIRE |
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