Stick-slip dynamics of migrating cells on viscoelastic substrates
| Autor: | Rumi De, Partho Sakha De |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
FOS: Physical sciences Slip (materials science) Condensed Matter - Soft Condensed Matter Models Biological 01 natural sciences Viscoelasticity Quantitative Biology::Cell Behavior 010305 fluids & plasmas Diffusion Physics::Fluid Dynamics Focal adhesion Cell Movement Cell Behavior (q-bio.CB) 0103 physical sciences Myosin Substrate stiffness Physics - Biological Physics 010306 general physics Tractive force Viscosity Time evolution Bond Force Mechanics Elasticity Nonlinear Sciences - Adaptation and Self-Organizing Systems body regions Biological Physics (physics.bio-ph) FOS: Biological sciences Soft Condensed Matter (cond-mat.soft) Quantitative Biology - Cell Behavior Adaptation and Self-Organizing Systems (nlin.AO) |
| Zdroj: | Physical Review E. 100 |
| ISSN: | 2470-0053 2470-0045 |
| DOI: | 10.1103/physreve.100.012409 |
| Popis: | Stick-slip motion, a common phenomenon observed during crawling of cells, is found to be strongly sensitive to the substrate stiffness. Stick-slip behaviours have previously been investigated typically using purely elastic substrates. For a more realistic understanding of this phenomenon, we propose a theoretical model to study the dynamics on a viscoelastic substrate. Our model based on a reaction-diffusion framework, incorporates known important interactions such as retrograde flow of actin, myosin contractility, force dependent assembly and disassembly of focal adhesions coupled with cell-substrate interaction. We show that consideration of a viscoelastic substrate not only captures the usually observed stick-slip jumps, but also predicts the existence of an optimal substrate viscosity corresponding to maximum traction force and minimum retrograde flow which was hitherto unexplored. Moreover, our theory predicts the time evolution of individual bond force that characterizes the stick-slip patterns on soft versus stiff substrates. Our analysis also elucidates how the duration of the stick-slip cycles are affected by various cellular parameters. |
| Databáze: | OpenAIRE |
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