Synthesis and Transformations of 3-Ethoxycarbonyl-2-(N-R-thioureido)thiophenes

Autor: T. V. Dolishnyak, A. N. Krasovsky, L. Yu. Chumakova, A. M. Demchenko, M. O. Lozinskii
Rok vydání: 2003
Předmět:
Zdroj: Chemistry of Heterocyclic Compounds. 39:1002-1012
ISSN: 0009-3122
DOI: 10.1023/b:cohc.0000003515.53486.4d
Popis: 3-Ethoxycarbonyl-2-(N-R-thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophenes were obtained by the reaction of 2-amino-3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzo[b]thiophene with isothiocyanates and of 3-ethoxycarbonyl-2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene with primary and secondary amines. The cyclization paths of the products leading to derivatives of thieno[2,3-d]pyrimidine and thieno[2,3-d]-1,3-thiazine were studied. The corresponding S-substituted derivatives were obtained by the alkylation of 3-R-2-thioxo-3,4,5,6,7,8-hexahydrobenzo[b]thieno[2,3-d]pyrimidin-4-ones.
Databáze: OpenAIRE