Immunometabolism: A new target for improving cancer immunotherapy
| Autor: | Juan Li, Paul B. Fisher, Xianjun Fang, Yibao Ma, Xiang-Yang Wang, Shixian Chen, Wenjie Liu, Chunqing Guo |
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| Rok vydání: | 2019 |
| Předmět: |
T-Lymphocytes
medicine.medical_treatment Antineoplastic Agents Biology Article 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Neoplasms Tumor Microenvironment medicine Animals Humans Tumor microenvironment Cancer Immunotherapy Cellular Reprogramming medicine.disease Warburg effect Anaerobic glycolysis Immune System 030220 oncology & carcinogenesis Metabolome Cancer research Energy Metabolism Glycolysis Reprogramming Signal Transduction |
| Popis: | Fundamental metabolic pathways are essential for mammalian cells to provide energy, precursors for biosynthesis of macromolecules, and reducing power for redox regulation. While dysregulated metabolism (e.g., aerobic glycolysis also known as the Warburg effect) has long been recognized as a hallmark of cancer, recent discoveries of metabolic reprogramming in immune cells during their activation and differentiation have led to an emerging concept of “immunometabolism.” Considering the recent success of cancer immunotherapy in the treatment of several cancer types, increasing research efforts are being made to elucidate alterations in metabolic profiles of cancer and immune cells during their interplays in the setting of cancer progression and immunotherapy. In this review, we summarize recent advances in studies of metabolic reprogramming in cancer as well as differentiation and functionality of various immune cells. In particular, we will elaborate how distinct metabolic pathways in the tumor microenvironment cause functional impairment of immune cells and contribute to immune evasion by cancer. Lastly, we highlight the potential of metabolically reprogramming the tumor microenvironment to promote effective and long-lasting antitumor immunity for improved immunotherapeutic outcomes. |
| Databáze: | OpenAIRE |
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