Uptake of Ozone in Human Lungs and Its Relationship to Local Physiological Response

Autor:	James S. Ultman, Wade H. Reeser, Genea M. Lee, Lan Wang, Adekemi B. Taylor, Steve F. Arnold, Abdellaziz Ben-Jebria
Rok vydání:	2005
Předmět:	Adult Male Delta Inhalation exposure Inhalation Exposure Inhalation Respiratory rate Chemistry Health Toxicology and Mutagenesis Dead space Reproducibility of Results Toxicology Respiratory Function Tests Delta-v (physics) Oxidants Photochemical Ozone Animal science Anesthesia Breathing Humans Female Lung Tidal volume
Zdroj:	Inhalation Toxicology. 17:699-707
ISSN:	1091-7691 0895-8378
Popis:	To investigate whether intersubject variations in the dose of inhaled ozone (O(3)) cause corresponding variations in the physiological response, 28 female and 32 male nonsmokers participated in a 1-h continuous inhalation of clean air or 0.25 ppm O(3) while exercising on a cycle ergometer at a constant ventilation rate of 30 L/min. The exposure protocols included continuous monitoring of respiratory flow rate and O(3) concentration from which O(3) uptake (OZU) and fractional uptake efficiency (UE) were computed. Pre-to-post changes in forced expired volume in 1 s (%DeltaFEV(1)), peripheral cross section for carbon dioxide diffusion (%Delta A(P)), and Fowler dead space volume (V(D)) were also measured for each exposure. Individual values of UE ranged from .70 to .98 among all the subjects, with significant differences (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6210e40869196ce95563a09e292efe8 https://doi.org/10.1080/08958370500224433 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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