Relationship between nulliparity and preeclampsia may be explained by altered circulating soluble fms-like tyrosine kinase 1
| Autor: | Tali Bdolah-Abram, Caryn Greenfield, Yuval Bdolah, Ariel Milwidsky, Shira Natanson-Yaron, S. Ananth Karumanchi, Uriel Elchalal, Drorith Hochner-Celnikier, Hadas Yechiam, Simcha Yagel, Debra Goldman-Wohl, Sarosh Rana |
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| Rok vydání: | 2013 |
| Předmět: |
Placental growth factor
Adult medicine.medical_specialty Angiogenesis Birth weight Pregnancy Trimester Third Pregnancy Proteins Preeclampsia Young Adult Pre-Eclampsia Pregnancy Internal medicine Internal Medicine medicine Humans Young adult Placenta Growth Factor Fetus Vascular Endothelial Growth Factor Receptor-1 business.industry Obstetrics and Gynecology medicine.disease Parity Endocrinology Female business Soluble fms-like tyrosine kinase-1 |
| Zdroj: | Hypertension in pregnancy. 33(2) |
| ISSN: | 1525-6065 |
| Popis: | To test the hypothesis that the risk of preeclampsia in nulliparous women may be due to an anti-angiogenic state.Maternal serum samples obtained in the third trimester from nulliparous (n = 86) and multiparous (n = 165) singleton uncomplicated pregnancies were analyzed for levels of angiogenic factors - soluble fms like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) by enzyme-linked immunosorbent assay (ELISA).For nulliparous and multiparous pregnancies, serum sFlt1 levels were 12 732 ± 832 and 10 162 ± 666 (p = 0.020), serum PlGF levels were 215 ± 15 and 249 ± 14 (p = 0.093) (all reported as mean SD in pg/ml) and mean ratios of sFlt1/PlGF were 93 ± 12 and 62 ± 5 (p = 0.023), respectively. Adjustment for maternal age and fetal birth weight did not alter the results.Nulliparous pregnancies had higher circulating sFlt1 levels and sFlt1/PlGF ratios than multiparous pregnancies, suggesting an association with an angiogenic imbalance. Taken together with the pathogenic role of anti-angiogenic factors in preeclampsia, our data may be one explanation for the epidemiological observation that nulliparity is a risk factor for the development of preeclampsia. |
| Databáze: | OpenAIRE |
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