Correction to: Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease
| Autor: | Mohamed El Kassas, Housam M. Hassan, Shimaa Afify Mansour, Dalia Omran, Amr Abd El-Aal, Magdy Ismail, Waleed M. Hassan, Ahmed Gaafar, Mohamed Alboraie, Adel ElTahan, Mohamed-Naguib Wifi, Yasser AbdelRahman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system business.industry MEDLINE Correction 030204 cardiovascular system & hematology Chronic liver disease medicine.disease QT interval 03 medical and health sciences 0302 clinical medicine lcsh:RC666-701 Internal medicine Medicine In patient 030212 general & internal medicine business |
| Zdroj: | The Egyptian Heart Journal, Vol 71, Iss 1, Pp 1-1 (2019) The Egyptian Heart Journal |
| Popis: | Hepatitis C virus (HCV) is a common disease in Egypt with a high socioeconomic burden and extra-hepatic manifestations as QT prolongation, but previous studies included mainly patients with advanced liver disease, so in this study, we aimed to delineate the prevalence of QT prolongation in early-stage HCV patients.The study included 874 HCV patients with early cirrhosis; in Child's class A, 57 (6.5%) patients had prolonged QT interval corrected (QTc). There was significant higher proportion of cirrhotic patients in the prolonged QTc group (31.6%) vs. in the normal QTc group (11.5%). QTc was 424.39 ± 36.6 vs. 411.51 ± 32.89 ms in cirrhotic and non-cirrhotic patients, respectively (P, 0.001). There was significant higher proportion of Fibrosis 4 (FIB-4) ≥ 1.45 score in the prolonged QTc (77.2%) vs. in the normal QTc group (56.8%) (P, 0.003). QTc interval was 417.76 ± 34.12 ms in patients with FIB-4 score ≥ 1.45 vs. 406.78 ± 31.95 ms in those with FIB-41.45 (P,0.001). FIB-4 score value of 2.108 predicted prolonged QTc with a sensitivity of 63.2% and a specificity of 64.5% (P,0.001). Twenty-four patients of long QTc group sent ECGs after HCV eradication, and 19 patients (79%) showed QTc normalization.HCV is associated with QTc prolongation even in patients with early chronic liver disease stages without significant fibrosis. Also, it is related to the degree of fibrosis and cirrhosis. At a cutoff value of 2.108, FIB-4 score can predict prolonged QTc. HCV eradication is associated with a high incidence of QTc normalization. |
| Databáze: | OpenAIRE |
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