Fifty percent nitrous oxide depresses recovery from anoxic heart failure induced by 100% nitrous oxide
| Autor: | Teruo Kumazawa, Shinichi Hinohara, Satoshi Kashimoto |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty Cardiac output Glycogen business.industry organic chemicals chemistry.chemical_element Nitrous oxide equipment and supplies medicine.disease Anoxic waters Oxygen chemistry.chemical_compound Anesthesiology and Pain Medicine chemistry Anesthesia Heart failure Internal medicine Cardiology medicine bacteria Energy charge business Heart metabolism |
| Zdroj: | Journal of Anesthesia. 1:119-124 |
| ISSN: | 1438-8359 0913-8668 |
| Popis: | In experiments on an isolated rate heart lung preparation, the effects of 100% oxygen, 50% nitrous oxide or air on myocardial metabolism during recovery from anoxic heart failure were evaluated with intramyocardial high energy phosphates, lactate and glycogen. A hundred percent nitrous oxide was administered until the cardiac output decreased from 30 to 20 ml/min, and then 50% nitrous oxide, air or 100% oxygen was administered. Fifty percent nitrous oxide reduced the cardiac output and caused heart failure again. The ATP level and energy charge in hearts with 50% nitrous oxide were significantly lower than those in the others. These data indicate that 50% nitrous oxide during recovery from anoxic heart failure had deleterious effects on myocardial function and metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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