Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials
| Autor: | Arpad Szallasi, Zsuzsanna Helyes, Fruzsina Kiss, Krisztina Pohóczky |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
malignant transformation
Cell Review Disease Catalysis Malignant transformation lcsh:Chemistry Inorganic Chemistry Pathogenesis Transient receptor potential channel Transient Receptor Potential Channels medicine Animals Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy TRP channels Squamous Cell Carcinoma of Head and Neck business.industry Organic Chemistry therapeutic target Cancer General Medicine medicine.disease head-and-neck squamous cell carcinoma Head and neck squamous-cell carcinoma Epithelium Computer Science Applications stomatognathic diseases medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Head and Neck Neoplasms Cancer research diagnostic and prognostic biomarker calcium influx business |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 6374, p 6374 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21176374 |
| Popis: | Head-and-neck squamous cell carcinomas (HNSCC) remain a leading cause of cancer morbidity and mortality worldwide. This is a largely preventable disease with smoking, alcohol abuse, and human papilloma virus (HPV) being the main risk factors. Yet, many patients are diagnosed with advanced disease, and no survival improvement has been seen for oral SCC in the past decade. Clearly, new diagnostic and prognostic markers are needed for early diagnosis and to guide therapy. Gene expression studies implied the involvement of transient receptor potential (TRP) channels in the pathogenesis of HNSCC. TRPs are expressed in normal epithelium where they play a key role in proliferation and differentiation. There is increasing evidence that the expression of TRP channels may change in HNSCC with important implications for diagnosis, prognosis, and therapy. In this review, we propose that TRP channel expression may afford a novel opportunity for early diagnosis of HNSCC and targeted molecular treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|