Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population
Autor: | Haishan Zhao, Yilin Wang, Qinghuan Xiao, Shu Guan, Wenyan Qin, Huizhe Wu, Weifan Yao, Minjie Wei, Miao He, Qiuchen Chen, Jing Zhang, Sainan Yin, Xiaoyun Hu, Zhen Zhang |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Risk
0301 basic medicine Oncology medicine.medical_specialty Genotype AKT1 lcsh:Medicine Single-nucleotide polymorphism medicine.disease_cause Polymorphism Single Nucleotide Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Asian People Neoplasms Internal medicine medicine Humans PTEN Genetic Predisposition to Disease lcsh:Science Protein kinase B PI3K/AKT/mTOR pathway Multidisciplinary biology business.industry TOR Serine-Threonine Kinases lcsh:R PTEN Phosphohydrolase Cancer medicine.disease 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis biology.protein lcsh:Q business Carcinogenesis Proto-Oncogene Proteins c-akt Signal Transduction |
Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | The pTEN/AKT/mTOR signaling pathways play a critical role in balancing cell proliferation, differentiation, and survival. Recent studies researched the associations of core genes in the pTEN/AKT/mTOR pathway polymorphisms with the cancer susceptibility; however, the results are inconclusive. Therefore, a systematically meta-analysis was performed to evaluate the association between the five SNPs (mTOR rs2295080 and rs2536, AKT1 rs2494750 and rs2494752, pTEN rs701848) and cancer risk by systematic review of the literature in 31 eligible studies. The results showed a significant decreased risk between rs2295080 TG, GG genotype, and GG/TG genotypes and overall cancer [TG vs.TT: OR(95% CI) = 0.82(0.76, 0.89), GG/TG vs. TT: OR(95% CI) = 0.82(0.76, 0.88), and GG vs. TG/TT: OR(95% CI) = 0.67(0.51, 0.88)] and the subgroup of urinary system cancer and digestive system cancer. Moreover, the SNP rs701848 CC, TC genotype showed significantly increased the overall cancer risk both in dominant model [CC/TC vs. TT: OR(95% CI) = 1.25(1.15, 1.36)] and recessive model [CC vs. TC/TT: OR(95% CI) = 1.20(1.09, 1.32)], and digestive system cancer and urinary system cancer. In addition, AG genotype and GG/AG genotype of rs2494752 was associated with increased risk of cancer. Therefore, this meta-analysis provided genetic risk factors for carcinogenesis and the most valid cancer prevalence estimate for Asian population. |
Databáze: | OpenAIRE |
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