Copper handling by astrocytes: Insights into neurodegenerative diseases
| Autor: | Evelyn Tiffany-Castiglioni, Sandra Hong, Yongchang Qian |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Central Nervous System
Parkinson's disease Cu toxicity Central nervous system Neurodegenerative Diseases Disease Biology medicine.disease Disease Models Animal medicine.anatomical_structure Developmental Neuroscience Cell culture Astrocytes Genetic model medicine Animals Humans Menkes disease Neuroscience Copper Developmental Biology Astrocyte |
| Zdroj: | International Journal of Developmental Neuroscience. 29:811-818 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2011.09.004 |
| Popis: | Copper (Cu) is an essential trace element in the brain that can be toxic at elevated levels. Cu accumulation is a suspected etiology in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and prion-induced disorders. Astrocytes are a proposed depot in the brain for Cu and other metals, including lead (Pb). This article describes the physiological roles of Cu in the central nervous system and in selected neurodegenerative diseases, and reviews evidence that astrocytes accumulate Cu and protect neurons from Cu toxicity. Findings from murine genetic models of Menkes disease and from cell culture models concerning the molecular mechanisms by which astrocytes take up, store, and buffer Cu intracellularly are discussed, as well as potential mechanistic linkages between astrocyte functions in Cu handling and neurodegenerative diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text