Characterization of chitosan–magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine
| Autor: | Satit Puttipipatkhachorn, Keith C. Gordon, Wanwisa Khunawattanakul, Clare J. Strachan, Thaned Pongjanyakul, Thomas Rades |
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| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
Nicotine Materials science Surface Properties Magnesium Compounds 02 engineering and technology 030226 pharmacology & pharmacy Biochemistry Nanocomposites Chitosan 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Structural Biology Spectroscopy Fourier Transform Infrared parasitic diseases Magnesium Aluminum Compounds Molecular Biology Drug Carriers Nanocomposite Silicates fungi Mouth Mucosa General Medicine Adhesion Buccal administration Permeation 021001 nanoscience & nanotechnology Evaporation (deposition) Membrane chemistry Aluminum Silicates lipids (amino acids peptides and proteins) 0210 nano-technology Drug carrier hormones hormone substitutes and hormone antagonists Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules. 55:24-31 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2012.12.043 |
| Popis: | The objective of this study was to prepare and characterize chitosan-magnesium aluminum silicate (CS-MAS) nanocomposite films as a buccal delivery system for nicotine (NCT). The effects of the CS-MAS ratio on the physicochemical properties, release and permeation, as well as on the mucoadhesive properties, were investigated. Molecular interactions between the components of the film were also investigated. The results indicated that NCT-loaded CS-MAS films provided a higher NCT content than NCT-loaded films containing only CS. The greater the MAS ratio in the films, the higher the NCT content that was observed because intercalated nanocomposites could be formed by electrostatic interactions of MAS with NCT and CS. These interactions caused an insignificant loss of NCT by evaporation during film drying. The release and permeation of NCT were related to the square root of time, indicating that a diffusion-controlled mechanism via the NCT-MAS complex particles and the film matrix controls NCT release. NCT release and permeation rates decreased with as the MAS ratio of the films was increased. However, the NCT-loaded CS-MAS films may have a potential adhesion to the mucosal membrane. These findings suggest that NCT-loaded CS-MAS films can be used as a buccal NCT delivery system. |
| Databáze: | OpenAIRE |
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