Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case–control studies

Autor: Lambertus A. Kiemeney, Klaus Kaae Andersen, Melissa C. Larson, Pamela J. Thompson, Mitul Shah, Kathryn L. Terry, Alice S. Whittemore, Michael E. Carney, Kunle Odunsi, Harvey A. Risch, Mette Tuxen Faber, Aleksandra Gentry-Maharaj, Allan Jensen, Robert A. Vierkant, Jenny Chang-Claude, Celeste Leigh Pearce, Penelope M. Webb, Urmila Chandran, Jennifer A. Doherty, Hannah P. Yang, Ellen L. Goode, Joellen M. Schildkraut, Susanne K. Kjaer, Karin A. Kasza, Anne M. van Altena, Galina Lurie, Simon A. Gayther, Oluwatosin Odunsi-Akanji, Robert P. Edwards, Elisa V. Bandera, Usha Menon, Allison F. Vitonis, Anna H. Wu, Honglin Song, Nicolas Wentzensen, Louise A. Brinton, Clareann H. Bunker, Sara H. Olson, Francesmary Modugno, Marc T. Goodman, Susan J. Ramus, Brooke L. Fridley, Mary Anne Rossing, Sita H. Vermeulen, Rebecca Sutphen, Paul D. Pharaoh, Roberta B. Ness, Susan J. Jordan, Valerie McGuire, Kirsten B. Moysich, Melony King, Christian Dehlendorff, Weiva Sieh, Jolanta Lissowska, Estrid Høgdall, Leon F.A.G. Massuger, Malcolm C. Pike, Daniel W. Cramer
Rok vydání: 2013
Předmět:
Adult
Oncology
Cancer Research
medicine.medical_specialty
endocrine system diseases
Adolescent
Aetiology
screening and detection [ONCOL 5]
Carcinoma
Ovarian Epithelial
Article
Molecular epidemiology [NCEBP 1]
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Translational research [ONCOL 3]
Internal medicine
Epidemiology
medicine
Carcinoma
Humans
Neoplasms
Glandular and Epithelial
Young adult
Aged
Molecular epidemiology Aetiology
screening and detection [NCEBP 1]
030304 developmental biology
Aged
80 and over
Ovarian Neoplasms
Gynecology
0303 health sciences
Hereditary cancer and cancer-related syndromes [ONCOL 1]
business.industry
Smoking
Case-control study
Cancer
Middle Aged
medicine.disease
Aetiology
screening and detection Immune Regulation [ONCOL 5]
3. Good health
Logistic Models
Case-Control Studies
030220 oncology & carcinogenesis
Meta-analysis
Female
business
Ovarian cancer
Risk assessment
Zdroj: Cancer Causes & Control; Vol 24
Cancer Causes & Control, 24, 5, pp. 989-1004
Cancer Causes & Control, 24, 989-1004
ISSN: 1573-7225
0957-5243
Popis: Contains fulltext : 118139.pdf (Publisher’s version ) (Closed access) PURPOSE: The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology. METHODS: We used data from 21 case-control studies of ovarian cancer (19,066 controls, 11,972 invasive and 2,752 borderline cases). Study-specific odds ratios (OR) and 95 % confidence intervals (CI) were obtained from logistic regression models and combined into a pooled odds ratio using a random effects model. RESULTS: Current cigarette smoking increased the risk of invasive mucinous (OR = 1.31; 95 % CI: 1.03-1.65) and borderline mucinous ovarian tumors (OR = 1.83; 95 % CI: 1.39-2.41), while former smoking increased the risk of borderline serous ovarian tumors (OR = 1.30; 95 % CI: 1.12-1.50). For these histological types, consistent dose-response associations were observed. No convincing associations between smoking and risk of invasive serous and endometrioid ovarian cancer were observed, while our results provided some evidence of a decreased risk of invasive clear cell ovarian cancer. CONCLUSIONS: Our results revealed marked differences in the risk profiles of histological types of ovarian cancer with regard to cigarette smoking, although the magnitude of the observed associations was modest. Our findings, which may reflect different etiologies of the histological types, add to the fact that ovarian cancer is a heterogeneous disease.
Databáze: OpenAIRE
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