Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways
| Autor: | Laris Achlaug, Lena Lapkina-Gendler, Shoshana Yakar, Zvi Laron, Haim Werner, Danielle Yaron-Saminsky, Lina Somri, Karthik Nagaraj, Rive Sarfstein, Metsada Pasmanik-Chor |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system Genome wide profiling IGF1 Deficiency Genome-wide association study Review Disease Bioinformatics 03 medical and health sciences 0302 clinical medicine Neoplasms Laron syndrome medicine Humans Insulin-Like Growth Factor I lcsh:QH301-705.5 thioredoxin-interacting protein (TXNIP) INSULIN-LIKE GROWTH FACTOR I DEFICIENCY business.industry Tumor biology growth hormone receptor (GH-R) Oncogenes General Medicine medicine.disease Review article 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis IGF1 receptor (IGF1R) cancer protection business Genome-Wide Association Study Signal Transduction insulin-like growth factor 1 (IGF1) |
| Zdroj: | Cells, Vol 8, Iss 6, p 596 (2019) Cells |
| ISSN: | 2073-4409 |
| Popis: | Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenital IGF1 deficiency confers protection against the development of malignancies. This ‘experiment of nature’ reflects the critical role of IGF1 in tumor biology. The present review article provides an overview of recently conducted genome-wide profiling analyses aimed at identifying mechanisms and signaling pathways that are directly responsible for the link between life-time low IGF1 levels and protection from tumor development. The review underscores the concept that ‘data mining’ an orphan disease might translate into new developments in oncology. |
| Databáze: | OpenAIRE |
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