Synergistic Effects of Regular Walking and Alkaline Electrolyzed Water on Decreasing Inflammation and Oxidative Stress, and Increasing Quality of Life in Individuals with Type 2 Diabetes: A Community Based Randomized Controlled Trial
| Autor: | Adi Lukas Kurniawan, Christopher J. Gordon, Ching Wen Chang, Hsiu Ting Tsai, Yohanes Andy Rias |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology inflammation marker Clinical Biochemistry 030209 endocrinology & metabolism Inflammation Type 2 diabetes medicine.disease_cause Biochemistry Article law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial Quality of life law Internal medicine medicine oxidative stress 030212 general & internal medicine Molecular Biology Community based regular walking alkaline electrolyzed water business.industry lcsh:RM1-950 Cell Biology Malondialdehyde medicine.disease lcsh:Therapeutics. Pharmacology chemistry quality of life Single blind synergistic effects type 2 diabetes medicine.symptom business Oxidative stress |
| Zdroj: | Antioxidants Volume 9 Issue 10 Antioxidants, Vol 9, Iss 946, p 946 (2020) |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox9100946 |
| Popis: | Alkaline electrolyzed water (AEW) and walking are strongly recommended for ameliorating oxidative stress and inflammation. Nevertheless, there is a lack of information on the combination of both on alleviating inflammation, oxidative stress, and improving the quality of life (QoL). We investigated the synergistic effects of drinking AEW and walking on advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), white blood cells (WBCs), neutrophil-lymphocyte ratio (NLR) and QoL. In total, 81 eligible patients with type 2 diabetes (T2DM) were randomly allocated via single blind to four groups: consumed 2 L/day of AEW (n = 20), instructed to walk for 150 min/week (n = 20), received a combination of AEW and walking (n = 20), and continue their habitual diet and activity (n = 21). Data were collected and analyzed before and after 8 weeks of intervention. Our results showed a significant interaction between the group and time, with both AEW and walking independently and synergistically ameliorating AGEs, AOPPs, MDA, NLR and WBCs levels. Moreover, the AEW group had a higher physical and total QoL score. The walking group and the combined group had higher scores in physical, mental and total QoL compared to the control group. The synergistic effect of AEW and regular walking are an advisable treatment for patients with T2DM. |
| Databáze: | OpenAIRE |
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