Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms

Autor:	Huan Ge, Caolin Wang, Chaoquan Tian, Yanyan Diao, Wanqi Wang, Xiangyu Ma, Jian Zhang, Honglin Li, Zhenjiang Zhao, Lili Zhu
Rok vydání:	2022
Předmět:	Pharmacology Mice Disease Models Animal Myeloproliferative Disorders Neoplasms Mutation Animals Apoptosis General Medicine Janus Kinase 2 Cell Proliferation
Zdroj:	Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 156
ISSN:	1950-6007
Popis:	Hyperactivation of the Janus kinase 2 (JAK2) signaling pathway leads to myeloproliferative neoplasms (MPNs) and targeting JAK2 can be used as an effective strategy for the treatment of MPNs. Here, our study indicated that WWQ-131 was a highly selective JAK2 inhibitor (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60b42f4836a75c2f7cd87b89d92e5d0 https://pubmed.ncbi.nlm.nih.gov/36306591 Zobrazit plný text záznamu Full Text from ScienceDirect