Incidence and pathophysiological changes in chronic two-kidney hypertension in the dog
| Autor: | B. E. Watkins, James O. Davis, R. C. Hanson, TE Lohmeier, Ronald H. Freeman |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Hypertension Renal Blood Pressure Plasma renin activity Renovascular hypertension chemistry.chemical_compound Dogs Heart Rate Physiology (medical) Internal medicine Renin Renin–angiotensin system medicine Animals business.industry Angiotensin II Sodium medicine.disease Endocrinology Blood pressure chemistry Pathophysiology of hypertension Renal blood flow Cardiology Female Corticosterone Saralasin business |
| Zdroj: | American Journal of Physiology-Legacy Content. 231:954-960 |
| ISSN: | 0002-9513 |
| Popis: | Unilateral renal artery plication in dogs reduced renal blood flow by 80% and produced a sustained elevation in arterial pressure whereas plasma renin activity increased for only 4 days. Sodium was retained for 3 days after plication, but this response is similar to that after a sham operation. Of seven dogs studied chronically, elevated arterial pressure was sustained for 27 days or longer in six animals. In three dogs hypertension continued for 2 mo before collateral vessels developed and arterial pressure fell; ligation of these collaterals restored hypertension. Arterial pressure was unaffected by an infusion of [1-sarcosine, 8-alanine] angiotensin II in chronic hypertensive dogs on a normal sodium intake. This angiotensin antagonist lowered arterial pressure after sodium depletion, but became ineffective following rapid sodium repletion. Chronic hypertensive dogs showed normal responses to deoxycorticosterone acetate. These findings suggest that the renin-angiotensin system is not critically involved in maintenace of chronic two-kidney renovascular hypertension in the dog. The data also show that the homeostatic role played by the renin-angiotensin system in the maintenance of arterial pressure remained intact in chronic hypertension. |
| Databáze: | OpenAIRE |
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