Ectodysplasin regulates pattern formation in the mammalian hair coat
| Autor: | Min Zhang, Janice L. Brissette, Lorin Weiner, Anna Brancaccio, Caterina Missero |
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| Přispěvatelé: | Zhang, M, Brancaccio, A, Weiner, L, Missero, Caterina, Brissette, Jl |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
DNA Complementary Time Factors Transgene Molecular Sequence Data Mice Transgenic Biology Mice Endocrinology Dermis Internal medicine Follicular phase Genetics medicine Animals Humans Compartment (development) Transgenes Promoter Regions Genetic Process (anatomy) Skin Regulation of gene expression Models Genetic integumentary system Gene Expression Regulation Developmental Membrane Proteins Cell Biology Ectodysplasins Alkaline Phosphatase Cell biology medicine.anatomical_structure Microscopy Fluorescence Signal transduction Plasmids Signal Transduction |
| Zdroj: | genesis. 37:30-37 |
| ISSN: | 1526-968X 1526-954X |
| DOI: | 10.1002/gene.10230 |
| Popis: | In mammalian skin, hair follicles develop at regular intervals and with site-specific morphologies. This process generates distinct patterns of hair, but the mechanisms that establish these patterns remain largely unknown. Here we present evidence of follicular patterning by ectodysplasin-A1 (Eda-A1), a signaling protein necessary for the proper development of hair and other appendages. In transgenic mice, Eda-A1 was targeted to the epithelial compartment of the developing skin. At periodic locations, multiple hair follicles were induced side by side, without any interfollicular space. These follicles grew into the dermis as a fusion and subsequently branched to create discrete stalks and hair bulbs. Thus, at sites where interfollicular skin normally forms, hair follicles developed instead. This result shows that Eda-A1 can regulate basic developmental decisions, as cells were switched from interfollicular to follicular fates. Given these effects, it is likely that Eda-A1 is among the key regulators of pattern formation in the skin. |
| Databáze: | OpenAIRE |
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