Prolonged and biphasic respiratory depression following epidural buprenorphine
| Autor: | I. K. Holk, N.-H. Jensen, F. Molke Jensen, M. Ravnborg |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Anesthesia Epidural Male Time Factors Respiratory rate business.industry Respiration Buprenorphine chemistry.chemical_compound Anesthesiology and Pain Medicine chemistry Depression Chemical Statistical significance Anesthesia Carbon dioxide medicine Humans Respiratory system business Tidal volume Depression (differential diagnoses) Respiratory minute volume medicine.drug |
| Zdroj: | Anaesthesia. 42:470-475 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1987.tb04036.x |
| Popis: | Ventilatory sensitivity to carbon dioxide was measured in six healthy volunteers before, and at various times up to 20 hours after, administration of epidural buprenorphine 0.15 mg with a modified Read rebreathing technique. The carbon dioxide response curves were depressed in a time-dependent, prolonged and biphasic manner. Significant depression was seen in the intercept values at an end tidal carbon dioxide of 7.2 kPa, for mouth occlusion pressure (p less than 0.01), tidal volume (p less than 0.05) and minute ventilation (p less than 0.05). A significant reduction of slope was obtained only for minute ventilation. Linear regression of respiratory rate changes during carbon dioxide stimulation, did not reach statistical significance. In conclusion, these data indicate that epidural buprenorphine, despite a high lipid solubility, causes respiratory depression to the same extent as epidural morphine. Surveillance of patients who receive epidural buprenorphine for postoperative pain relief is necessary. |
| Databáze: | OpenAIRE |
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