Effects of different anesthesia and analgesia on cellular immunity and cognitive function of patients after surgery for esophageal cancer
| Autor: | Ming Tan, Jun Xiang, Rongyu Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Anesthesia
Epidural Male Cellular immunity medicine.medical_specialty Time Factors Esophageal Neoplasms Visual analogue scale medicine.medical_treatment Anesthesia General Group B 03 medical and health sciences 0302 clinical medicine Immune system Cognition T-Lymphocyte Subsets medicine Humans Anesthesia Thoracotomy Lymphocyte Count Adverse effect Pain Measurement Analgesics Immunity Cellular business.industry Analgesia Patient-Controlled Esophageal cancer Middle Aged medicine.disease Surgery Analgesia Epidural 030220 oncology & carcinogenesis Injections Intravenous 030211 gastroenterology & hepatology Female Analgesia business CD8 |
| Zdroj: | Minerva chirurgica. 75(6) |
| ISSN: | 1827-1626 |
| Popis: | BACKGROUND The study intends to analyze influences of different anesthesia and analgesia on cellular immune and cognitive functions of patients undergoing thoracotomy for esophageal cancer (EsC). METHODS Patients undergoing thoracotomy for EsC were divided into four groups: Group A (received general anesthesia [GA]) and postoperative intravenous analgesia); B (received GA and postoperative epidural analgesia); C (received GA combined with thoracic epidural anesthesia [TEA]) and postoperative intravenous analgesia); D (received GA combined with TEA and postoperative epidural analgesia). The T-lymphocyte subsets were determined at 30 min before anesthesia induction (T 0 ), 2 h after skin incision (T 1 ), and at 4 h (T 2 ), 24 h (T 3 ), and 48 h (T 4 ) after operation. Besides, visual analogue scale (VAS) and mini-mental state examination (MMSE) were assessed. RESULTS The percentage of CD3+ and CD4+ cells in groups B and C were higher than group A from T 1 to T 3 . The ratio of CD4+/CD8+ in group B and C were higher than in group A at T 3 . Compared with group A, group D had increased percentages of CD3+ and CD4+ from T 1 to T 4 , and elevated ratio of CD4+/CD8+ from T 2 to T 4 VAS scores were lower and MMSE scores were higher in groups B, C, and D than in group A, and group D had relatively lower VAS and higher MMSE scores as compared to group B. CONCLUSIONS The intraoperative general anesthesia combined with thoracic epidural anesthesia and postoperative epidural analgesia may reduce adverse effect on cellular immune and cognitive functions of patients undergoing thoracotomy for EsC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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