NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation
| Autor: | Jiatian Lin, Xiangling Chen, Hongjian Yu, Shasha Min, Yequn Chen, Zesong Li, Xina Xie |
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| Rok vydání: | 2022 |
| Předmět: |
Jumonji Domain-Containing Histone Demethylases
F-Box Proteins Lysine Cell Cycle Proteins Cell Biology Applied Microbiology and Biotechnology Kidney Neoplasms Demethylation Gene Expression Regulation Neoplastic Cell Line Tumor Humans Molecular Biology Carcinoma Renal Cell Ecology Evolution Behavior and Systematics Developmental Biology Cell Proliferation |
| Zdroj: | International journal of biological sciences. 18(9) |
| ISSN: | 1449-2288 |
| Popis: | The poor sensitivity of clear cell renal cell carcinoma (ccRCC) to conventional chemotherapy and radiotherapy makes its treatment challenging. The Ndc80 kinetochore complex component (NUF2) is involved in the development and progression of several cancers. However, its role in ccRCC remains unclear. In this study, we investigated the biological functions and underlying mechanism of NUF2 in ccRCC. We found that NUF2 expression was increased in ccRCC and associated with poor prognosis. Altering NUF2 level affected cell proliferation, migration, and invasion. Moreover, NUF2 acted as a potential oncogene to promote the progression of ccRCC through epigenetic activation of high-mobility group AT-hook 2 (HMGA2) transcription by suppressing lysine demethylase 2A expression and affecting its occupancy on the |
| Databáze: | OpenAIRE |
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