In vitro increase of the fluid-phase endocytosis induced by pulsed radiofrequency electromagnetic fields: importance of the electric field component
| Autor: | Lluis M. Mir, Philippe Lévêque, Nawel Mahrour, Stéphane Orlowski, Mihaela G. Moisescu, Roxana Pologea-Moraru |
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| Přispěvatelé: | Vectorologie et transfert de gènes (VTG / UMR8121), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Department of Biophysics, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), SBFM/DBJC, CEA and URA 2096 CNRS, Centre d'Etudes de Saclay, OSA, XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2003 |
| Předmět: |
Electromagnetic field
Materials science animal structures MESH: Biological Transport Biophysics MESH: Cricetinae Endocytosis Biochemistry MESH: Electromagnetic Fields Cell Line 03 medical and health sciences Mice 0302 clinical medicine Electromagnetic Fields Electric field Cricetinae Animals MESH: Animals [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] MESH: Mice 030304 developmental biology Envelope (waves) Fluorescent Dyes 0303 health sciences Component (thermodynamics) business.industry Pulsed radiofrequency Pulse duration Biological Transport Cell Biology MESH: Fluorescent Dyes 3. Good health MESH: Cell Line 030220 oncology & carcinogenesis MESH: Endocytosis Optoelectronics Fluid-phase endocytosis business |
| Zdroj: | Biochimica et Biophysica Acta-Molecular Cell Research Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2005, 1668 (1), pp.126-37. ⟨10.1016/j.bbamem.2004.11.015⟩ Biochimica et Biophysica Acta-Molecular Cell Research, 2005, 1668 (1), pp.126-37. ⟨10.1016/j.bbamem.2004.11.015⟩ |
| ISSN: | 0006-3002 0167-4889 |
| DOI: | 10.1016/j.bbamem.2004.11.015⟩ |
| Popis: | Nowadays, due to the wide use of mobile phones, the possible biological effects of electromagnetic fields (EMF) become a public health general concern. Despite intensive research, there are no widely accepted theories about the interactions between EMFs and living cells, and the experimental data are often controversial. We examined the effects of mobile phones EMF (envelope frequency of 217 Hz, carrier frequency of 900 MHz and pulse duration of 580 micros) or its pure, low-frequency pulsed electric field component on fluid-phase endocytosis. In both cases, with exposures exceeding 10 min, an increase of the fluid-phase endocytosis rate was observed ( approximately 1.5-fold), on three different cell types. This increase is an all-or-nothing type of response that is occurring for threshold values comprised between 1.3 and 2.6 W/kg for the delivered EMF powers and between 1.1 and 1.5 V/cm for the electric fields intensities depending upon the cell type. The electric component of these EMFs is shown to be responsible for the observed increase. Variations of frequency or pulse duration of the electric pulses are shown to be without effect. Thus, EMF, via their electrical component, can perturb one of the most fundamental physiological functions of the cells-endocytosis. |
| Databáze: | OpenAIRE |
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