The role of the gut microbiota in schizophrenia: Current and future perspectives
| Autor: | Carlos Spuch, Roberto Carlos Agis-Balboa, José M. Olivares, Maria Nieto-Araujo, Carolina Barreiro-Villar, Daniela Rodrigues-Amorim, María Elena de las Heras, Tania Rivera-Baltanás, Raul Vázquez-Noguerol Méndez, Benito Regueiro |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology business.industry Schizophrenia (object-oriented programming) Gut flora biology.organism_classification Epigenesis Genetic Gastrointestinal Microbiome 03 medical and health sciences Psychiatry and Mental health 030104 developmental biology 0302 clinical medicine Chronic disease Schizophrenia Medicine Humans Epigenetics business Neuroscience 030217 neurology & neurosurgery Biological Psychiatry |
| Zdroj: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 19(8) |
| ISSN: | 1814-1412 |
| Popis: | Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia.This review summarises and discusses currently available information, focussing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives.The connection between the microbiota, epigenetic mechanisms and technological developments allows for formulating new approaches objectively oriented towards the development of alternative psychotherapies that may help treat schizophrenia.In this review, the gut microbiota and epigenetic mechanisms were considered as key regulators, revealing a potential new aetiology of schizophrenia. Likewise, continuous technological advances (e.g. culturomics), aimed at the microbiota-gut-brain axis generate new evidence on this concept. |
| Databáze: | OpenAIRE |
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