Morphometric characteristics of neovascularization of carotid atherosclerotic plaques
| Autor: | Tat'yana S. Gulevskaya, Marine M. Tanashyan, Pavel L. Anufriev, K N Kulichenkova, A N Evdokimenko |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Carotid atherosclerosis
Pathology medicine.medical_specialty Connective tissue Hemorrhage Inflammation 030204 cardiovascular system & hematology Pathology and Forensic Medicine Atheromatosis Neovascularization 03 medical and health sciences 0302 clinical medicine Vessel density medicine Humans Statistical analysis Neovascularization Pathologic Chemistry Atherosclerosis medicine.disease Plaque Atherosclerotic Carotid Arteries medicine.anatomical_structure medicine.symptom 030217 neurology & neurosurgery Calcification |
| Zdroj: | Arkhiv patologii. 80:24 |
| ISSN: | 0004-1955 |
| DOI: | 10.17116/patol201880224-29 |
| Popis: | to identify the relationship between the magnitude of neovascularization of an atherosclerotic plaque and its other processes, such as atheromatosis, macrophage responses, hemorrhages, and calcification.48 carotid atherosclerotic plaques all their way underwent morphopathological examination, by assessing the magnitude of neovascularization (total vessel density per plague cmThere was a substantial variability in vessel diameters and densities in the plaque with a drastic predominance of vessels smaller than 20 µm in diameter (69.8±14.3%). The vessels with a diameter as large as 20 µm were more frequently located in the area of accumulation of foam cells or organizing hemorrhages (p0.03), unlike those with a diameter of more than 40 µm, which were more common in the areas of connective tissue, especially adjacent to large calcifications, and in the foci of organized hemorrhages (p0.008). Intensified calcification was accompanied by the higher density of vessels having a diameter of more than 40 µm (p0.038) and particularly of those with a diameter of more than 60 µm (p=0.006). The degree of hemorrhages and the number of foam cells were unrelated to the density of vessels, but these increased with their localization in the surface areas of a plaque (p=0.000342). With the increasing severity of atheromatosis, there was a decrease in the density of vessels larger than 20 µm in diameter (p=0.00042).The number, diameter, and location of vessels in the plaque serve as a dynamic reflection of its destructive and reparative processes; and a larger number of vessels having a diameter of more than 40 µm can be an indicator for the activation of reparative processes.Цель исследования - определить связи между степенью выраженности неоваскуляризации атеросклеротической бляшки и таких процессов в ней, как атероматоз, макрофагальная реакция, кровоизлияния и обызвествление. Материал и методы. Проведено патоморфологическое исследование 48 атеросклеротических бляшек каротидного синуса на всем их протяжении с оценкой степени выраженности неоваскуляризации (общая плотность сосудов на 1 см |
| Databáze: | OpenAIRE |
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