Acute Kidney Injuries in Children with Severe Malaria: A comparative study of diagnostic criteria based on serum cystatin C and creatinine levels
| Autor: | Olayinka Rasheed Ibrahim, Olugbenga A. Mokuolu, Olanrewaju T. Adedoyin, Mohammed Baba Abdulkadir, Ayodele Ojuawo, FM Afolayan, Sikiru Abayomi Biliaminu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adolescent Urology Clinical & Basic Research Renal function Nigeria urologic and male genital diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Renal Failure Prospective Studies Cystatin C Child Creatinine Kidney biology business.industry Incidence (epidemiology) Acute kidney injury Infant General Medicine Acute Kidney Injury medicine.disease female genital diseases and pregnancy complications Malaria 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies chemistry Child Preschool biology.protein Cystatin business Biomarkers 030215 immunology Kidney disease Glomerular Filtration Rate |
| Zdroj: | Sultan Qaboos University Medical Journal |
| ISSN: | 2075-0528 |
| Popis: | Objectives: Serum creatinine levels are often used to diagnose acute kidney injury (AKI), but may not necessarily accurately reflect changes in glomerular filtration rate (GFR). This study aimed to compare the prevalence of AKI in children with severe malaria using diagnostic criteria based on creatinine values in contrast to cystatin C. Methods: This prospective cross-sectional study was performed between June 2016 and May 2017 at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. A total of 170 children aged 0.5–14 years old with severe malaria were included. Serum cystatin C levels were determined using a particle-enhanced immunoturbidmetric assay method, while creatinine levels were measured using the Jaffe reaction. Renal function assessed using cystatin C-derived estimated GFR (eGFR) was compared to that measured using three sets of criteria based on creatinine values including the Kidney Disease: Improved Global Outcomes (KDIGO) and World Health Organization (WHO) criteria as well as an absolute creatinine cut-off value of >1.5 mg/dL. Results: Mean serum cystatin C and creatinine levels were 1.77 ± 1.37 mg/L and 1.23 ± 1.80 mg/dL, respectively (P = 0.002). According to the KDIGO, WHO and absolute creatinine criteria, the frequency of AKI was 32.4%, 7.6% and 16.5%, respectively. In contrast, the incidence of AKI based on cystatin C-derived eGFR was 51.8%. Overall, the rate of detection of AKI was significantly higher using cystatin C compared to the KDIGO, WHO and absolute creatinine criteria (P = 0.003 |
| Databáze: | OpenAIRE |
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