Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder
| Autor: | Catharina A. Hartman, Alejandro Arias-Vasquez, Cathelijne J. M. Buschgens, Ellen A. Fliers, Nanda Rommelse, Marieke E. Altink, Jan K. Buitelaar, Barbara Franke, Joseph A. Sergeant, Judith S. Nijmeijer, Ruud B. Minderaa, Pieter J. Hoekstra |
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| Přispěvatelé: | Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Candidate gene medicine.medical_specialty Genetic Linkage DEFICIT HYPERACTIVITY DISORDER Locus (genetics) SIB PAIRS Comorbidity Quantitative trait locus ASD TWIN SAMPLE Genetic linkage Surveys and Questionnaires Developmental and Educational Psychology medicine Genetics GENETIC INFLUENCES Attention deficit hyperactivity disorder Humans ADHD Attention SOCIAL-BEHAVIOR Psychiatry Child Genetic association GENERAL-POPULATION Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] WILLIAMS-BEUREN-SYNDROME Chromosome Mapping medicine.disease GENOME Autism spectrum disorder Attention Deficit Disorder with Hyperactivity Child Development Disorders Pervasive Autism Female Psychology Chromosomes Human Pair 7 TRAITS SCAN Clinical psychology |
| Zdroj: | Journal of Autism and Developmental Disorders, 44(7), 1671-1680. SPRINGER/PLENUM PUBLISHERS Journal of Autism and Developmental Disorders, 44, 1671-80 Journal of Autism and Developmental Disorders, 44, 7, pp. 1671-80 |
| ISSN: | 0162-3257 |
| DOI: | 10.1007/s10803-014-2039-4 |
| Popis: | Item does not contain fulltext We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing. |
| Databáze: | OpenAIRE |
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