Fresh-frozen Complete Extensor Mechanism Allograft versus Autograft Reconstruction in Rabbits
Autor: | Jian Zhao, Baoan Ma, Qingyu Fan, Yinglong Zhang, Qiong Ma, Hongtao Zhang, Guanyin Chen |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
musculoskeletal diseases
medicine.medical_specialty chemical and pharmacologic phenomena Osteocytes Bone-Patellar Tendon-Bone Grafting Article Quadriceps Muscle 03 medical and health sciences 0302 clinical medicine Vascularity Freezing medicine Animals Tibia Autografts 030222 orthopedics Multidisciplinary Infrapatellar fat pad business.industry Extensor mechanism 030229 sport sciences Anatomy Allografts musculoskeletal system Reflex Babinski Patellar tendon Biomechanical Phenomena Surgery surgical procedures operative medicine.anatomical_structure Models Animal Fresh frozen Rabbits Quadriceps tendon medicine.symptom business |
Zdroj: | Scientific Reports |
ISSN: | 2045-2322 |
DOI: | 10.1038/srep22106 |
Popis: | Different clinical results have been reported in the repair of extensor mechanism disruption using fresh-frozen complete extensor mechanism (CEM) allograft, creating a need for a better understanding of fresh-frozen CME allograft reconstruction. Here, we perform histological and biomechanical analyses of fresh-frozen CEM allograft or autograft reconstruction in an in vivo rabbit model. Our histological results show complete incorporation of the quadriceps tendon into the host tissues, patellar survival and total integration of the allograft tibia, with relatively fewer osteocytes, into the host tibia. Vascularity and cellularity are reduced and delayed in the allograft but exhibit similar distributions to those in the autograft. The infrapatellar fat pad provides the main blood supply and the lowest cellularity is observed in the patellar tendon close to the tibia in both the allograft and autograft. The biomechanical properties of the junction of quadriceps tendon and host tissues and those of the allograft patellar tendon are completely and considerably restored, respectively. Therefore, fresh-frozen CEM allograft reconstruction is viable, but the distal patellar tendon and the tibial block may be the weak links of the reconstruction. These findings provide new insight into the use of allograft in repairing disruption of the extensor mechanism. |
Databáze: | OpenAIRE |
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